Regulacion del volumen plasmatico y del volumen extracelular. The saltsensitive dahl s ss rat is a widely studied example of an animal that develops hypertension, associated with a shift of the pressure. The saltsensitive dahl s ss rat is a widely studied example of an animal that develops hypertension, associated with a shift of the. The specific intrarenal mechanism for the decrease in tubular reabsorption in response to increases in renal perfusion pressure appears to be related. Pressure natriuresis definition of pressure natriuresis. Pressure natriuresis and the control of arterial pressure. Mechanisms of pressurediuresis and pressurenatriuresis. Pressure natriuresis and the renal control of arterial. Jessica ivy is a british heart foundation phd student at the university of edinburgh. Natriuresis and glomerular hemodynamics in misunderstood reninangiotensinaldosterone system.
Animal models of salt andor angiotensin iiinduced chronic hypertension have revealed shifts in the observed pressurenatriuresis and pressurediuresis relationships to higher pressures, as well as altered renal blood flow regulation 16. Matt bailey is a renal physiologist with a phd from the university of london. The specific intrarenal mechanism for the decrease in tubular reabsorption in response to increases in renal perfusion pressure appears to be. Natriuresis lowers the concentration of sodium in the blood and also tends to lower blood volume because osmotic forces drag water out of the bodys blood circulation.
Pressure natriuresis and diuresis occur together not able to control sodium and water independently independent of vasomotor activity in effect, isotonic urine is excreted to reduce blood volume though urine not necessarily actually isotonic volume status. Mcgrawhill dictionary of scientific and technical terms, 6th ed sodio. A central component of the feedback system for longterm control of arterial pressure is the pressurenatriuresis mechanism, whereby increases in renal perfusion pressure lead to decreases in sodium reabsorption and increases in sodium excretion. It is promoted by ventricular and atrial natriuretic peptides as well as calcitonin, and inhibited by chemicals such as aldosterone. Her phd combines in vivo approaches for cardiovascular and renal physiology with molecular techniques to explore the mechanisms of saltsensitive hypertension. The degree of pressure natriuresis and diuresis is dependent on volume status. He had postdoctoral training at ucl, cnrs in saclay, france and yale. Pressure diuresis definition of pressure diuresis by.